Variation Browser
DownloadReceptor | Position | GPCRdb | Segment | Variant | Mutation type | Allele Frequency | Allele Count | Allele Number | Homozygotes | SIFT score | PolyPhen score | Functional annotation |
---|---|---|---|---|---|---|---|---|---|---|---|---|
Receptor | Position | GPCRdb | Segment | Variant | Mutation Type | Allele Frequency | Allele Count | Allele Number | Homozygotes | SIFT score | PolyPhen score | Functional annotation |
5ht7r_human | 474 | C-term | K => SerfsTer2 | frameshift | 8.303e-06 | 1 | 120438 | 0 | None | None | ||
5ht7r_human | 462 | C-term | W => Ter | stop gained | 8.241e-06 | 1 | 121346 | 0 | None | None | ||
5ht7r_human | 403 | 8.62x62 | H8 | Y => Ter | stop gained | 8.238e-06 | 1 | 121382 | 0 | None | None | |
5ht7r_human | 301 | ICL3 | E => Ter | stop gained | 8.266e-06 | 1 | 120976 | 0 | None | None | ||
5ht7r_human | 221 | ECL2 | W => Ter | stop gained | 8.242e-06 | 1 | 121328 | 0 | None | None | ||
5ht7r_human | 470 | C-term | T => A | missense | 8.324e-06 | 1 | 120138 | 0 | nan | 0.003 | ||
5ht7r_human | 466 | C-term | K => Q | missense | 8.355e-06 | 1 | 119682 | 0 | nan | 0.952 | ||
5ht7r_human | 464 | C-term | A => V | missense | 1.648e-05 | 2 | 121344 | 0 | nan | 0.0 | ||
5ht7r_human | 464 | C-term | A => T | missense | 8.241e-06 | 1 | 121342 | 0 | nan | 0.0 | ||
5ht7r_human | 457 | C-term | P => S | missense | 8.24e-06 | 1 | 121360 | 0 | nan | 0.0 | ||
5ht7r_human | 454 | C-term | L => P | missense | 8.24e-06 | 1 | 121364 | 0 | nan | 0.0 | ||
5ht7r_human | 454 | C-term | L => V | missense | 8.24e-06 | 1 | 121364 | 0 | nan | 0.0 | ||
5ht7r_human | 451 | C-term | V => L | missense | 1.648e-05 | 2 | 121374 | 0 | nan | 0.0 | ||
5ht7r_human | 449 | C-term | V => A | missense | 7.415e-05 | 9 | 121368 | 0 | 1.0 | 0.0 | ||
5ht7r_human | 449 | C-term | V => L | missense | 8.239e-06 | 1 | 121368 | 0 | nan | 0.0 | ||
5ht7r_human | 448 | C-term | P => R | missense | 0.008265 | 1003 | 121356 | 13 | nan | 0.0 | ||
5ht7r_human | 448 | C-term | P => L | missense | 4.944e-05 | 6 | 121356 | 1 | nan | 0.0 | ||
5ht7r_human | 448 | C-term | P => T | missense | 8.24e-06 | 1 | 121358 | 0 | nan | 0.0 | ||
5ht7r_human | 448 | C-term | P => S | missense | 8.24e-06 | 1 | 121358 | 0 | nan | 0.0 | ||
5ht7r_human | 446 | C-term | R => K | missense | 1.648e-05 | 2 | 121354 | 0 | nan | 0.001 | ||
5ht7r_human | 445 | C-term | K => N | missense | 0.0003049 | 37 | 121354 | 0 | nan | 0.0 | ||
5ht7r_human | 443 | C-term | P => S | missense | 1.648e-05 | 2 | 121344 | 0 | nan | 0.001 | ||
5ht7r_human | 439 | C-term | V => L | missense | 8.241e-06 | 1 | 121344 | 0 | nan | 0.0 | ||
5ht7r_human | 433 | C-term | R => K | missense | 8.244e-06 | 1 | 121296 | 0 | nan | 0.0 | ||
5ht7r_human | 427 | C-term | R => K | missense | 8.355e-06 | 1 | 119682 | 0 | nan | 0.001 | ||
5ht7r_human | 427 | C-term | R => G | missense | 8.349e-06 | 1 | 119770 | 0 | nan | 0.027 | ||
5ht7r_human | 425 | C-term | P => T | missense | 8.317e-06 | 1 | 120234 | 0 | nan | 0.65 | ||
5ht7r_human | 416 | C-term | H => R | missense | 3.302e-05 | 4 | 121130 | 0 | 0.11 | 0.999 | ||
5ht7r_human | 416 | C-term | H => L | missense | 8.256e-06 | 1 | 121130 | 0 | 0.01 | 0.999 | ||
5ht7r_human | 410 | C-term | L => F | missense | 2.473e-05 | 3 | 121318 | 0 | 0.0 | 0.999 | ||
5ht7r_human | 405 | C-term | N => T | missense | 8.24e-06 | 1 | 121360 | 0 | 0.03 | 0.983 | ||
5ht7r_human | 400 | 8.59x59 | H8 | Q => R | missense | 8.238e-06 | 1 | 121390 | 0 | 0.5 | 0.003 | |
5ht7r_human | 400 | 8.59x59 | H8 | Q => E | missense | 8.238e-06 | 1 | 121392 | 0 | 0.27 | 0.117 | |
5ht7r_human | 396 | 8.55x55 | H8 | R => C | missense | 8.237e-06 | 1 | 121402 | 0 | 0.0 | 0.886 | |
5ht7r_human | 389 | 8.48x48 | H8 | R => Q | missense | 8.237e-06 | 1 | 121398 | 0 | 0.03 | 1.0 | GP (contact) |
5ht7r_human | 389 | 8.48x48 | H8 | R => W | missense | 1.648e-05 | 2 | 121396 | 0 | 0.0 | 1.0 | GP (contact) |
5ht7r_human | 382 | 7.51x51 | TM7 | F => L | missense | 8.238e-06 | 1 | 121390 | 0 | 0.59 | 0.084 | |
5ht7r_human | 378 | 7.47x47 | TM7 | L => F | missense | 1.648e-05 | 2 | 121372 | 0 | 0.19 | 0.999 | |
5ht7r_human | 377 | 7.46x46 | TM7 | S => C | missense | 8.24e-06 | 1 | 121366 | 0 | 0.03 | 1.0 | |
5ht7r_human | 372 | 7.41x40 | TM7 | L => P | missense | 8.241e-06 | 1 | 121342 | 0 | 0.0 | 1.0 | |
5ht7r_human | 369 | 7.38x37 | TM7 | F => C | missense | 8.242e-06 | 1 | 121330 | 0 | 0.11 | 0.03 | |
5ht7r_human | 362 | 7.31x30 | TM7 | P => S | missense | 1.649e-05 | 2 | 121294 | 0 | 0.02 | 1.0 | |
5ht7r_human | 358 | ECL3 | C => Y | missense | 8.246e-06 | 1 | 121274 | 0 | 0.01 | 1.0 | ||
5ht7r_human | 358 | ECL3 | C => F | missense | 8.246e-06 | 1 | 121274 | 0 | 0.01 | 1.0 | ||
5ht7r_human | 356 | ECL3 | T => S | missense | 8.246e-06 | 1 | 121264 | 0 | 0.55 | 0.039 | ||
5ht7r_human | 349 | 6.57x57 | TM6 | A => V | missense | 1.649e-05 | 2 | 121250 | 0 | 0.71 | 0.999 | |
5ht7r_human | 346 | 6.54x54 | TM6 | L => I | missense | 8.248e-06 | 1 | 121238 | 0 | 0.04 | 0.817 | |
5ht7r_human | 344 | 6.52x52 | TM6 | F => I | missense | 8.249e-06 | 1 | 121232 | 0 | 0.0 | 1.0 | LB (aromatic (edge-to-face), polar (hydrogen bond)) |
5ht7r_human | 338 | 6.46x46 | TM6 | V => M | missense | 3.3e-05 | 4 | 121214 | 0 | 0.06 | 0.104 | |
5ht7r_human | 337 | 6.45x45 | TM6 | T => I | missense | 8.249e-06 | 1 | 121224 | 0 | 0.08 | 0.889 | |
5ht7r_human | 335 | 6.43x43 | TM6 | A => V | missense | 3.3e-05 | 4 | 121218 | 0 | 0.08 | 0.534 | |
5ht7r_human | 335 | 6.43x43 | TM6 | A => T | missense | 8.249e-06 | 1 | 121220 | 0 | 0.02 | 0.983 | |
5ht7r_human | 335 | 6.43x43 | TM6 | A => S | missense | 1.65e-05 | 2 | 121220 | 0 | 0.01 | 0.98 | |
5ht7r_human | 333 | 6.41x41 | TM6 | V => I | missense | 3.3e-05 | 4 | 121194 | 0 | 0.02 | 0.958 | |
5ht7r_human | 326 | 6.34x34 | TM6 | A => T | missense | 8.251e-06 | 1 | 121192 | 0 | 0.22 | 0.999 | SodiumPocket MicroSwitch |
5ht7r_human | 325 | 6.33x33 | TM6 | A => V | missense | 8.251e-06 | 1 | 121192 | 0 | 0.03 | 0.999 | GP (contact) |
5ht7r_human | 299 | ICL3 | V => M | missense | 8.266e-06 | 1 | 120982 | 0 | 0.13 | 0.905 | ||
5ht7r_human | 292 | ICL3 | I => K | missense | 1.653e-05 | 2 | 120976 | 0 | 0.89 | 0.004 | ||
5ht7r_human | 292 | ICL3 | I => V | missense | 8.266e-06 | 1 | 120978 | 0 | 0.53 | 0.002 | ||
5ht7r_human | 286 | ICL3 | V => I | missense | 8.266e-05 | 10 | 120982 | 0 | 0.22 | 0.01 | ||
5ht7r_human | 285 | ICL3 | S => N | missense | 8.263e-06 | 1 | 121024 | 0 | 0.51 | 0.395 | PTM (Phosphorylation) | |
5ht7r_human | 285 | ICL3 | S => G | missense | 1.653e-05 | 2 | 121020 | 0 | 0.43 | 0.006 | PTM (Phosphorylation) | |
5ht7r_human | 284 | ICL3 | D => H | missense | 8.263e-06 | 1 | 121024 | 0 | 0.15 | 0.617 | ||
5ht7r_human | 280 | ICL3 | R => Q | missense | 9.089e-05 | 11 | 121030 | 0 | 0.11 | 0.124 | ||
5ht7r_human | 279 | ICL3 | P => L | missense | 0.002049 | 248 | 121050 | 0 | 0.0 | 0.082 | ||
5ht7r_human | 271 | 5.70x70 | TM5 | A => G | missense | 8.251e-06 | 1 | 121202 | 0 | 0.1 | 0.88 | |
5ht7r_human | 261 | 5.60x60 | TM5 | Q => R | missense | 2.473e-05 | 3 | 121306 | 0 | 0.75 | 0.006 | |
5ht7r_human | 258 | 5.57x57 | TM5 | M => T | missense | 8.244e-06 | 1 | 121302 | 0 | 0.0 | 0.998 | |
5ht7r_human | 258 | 5.57x57 | TM5 | M => V | missense | 8.244e-06 | 1 | 121304 | 0 | 0.38 | 0.994 | |
5ht7r_human | 256 | 5.55x55 | TM5 | L => I | missense | 8.243e-06 | 1 | 121312 | 0 | 0.18 | 0.999 | |
5ht7r_human | 254 | 5.53x53 | TM5 | V => I | missense | 1.649e-05 | 2 | 121316 | 0 | 0.05 | 0.923 | |
5ht7r_human | 254 | 5.53x53 | TM5 | V => F | missense | 8.243e-06 | 1 | 121316 | 0 | 0.0 | 0.999 | |
5ht7r_human | 249 | 5.48x48 | TM5 | Y => F | missense | 8.242e-06 | 1 | 121328 | 0 | 0.0 | 1.0 | |
5ht7r_human | 241 | 5.40x41 | TM5 | I => S | missense | 8.241e-06 | 1 | 121348 | 0 | 0.0 | 0.959 | |
5ht7r_human | 240 | 5.39x40 | TM5 | T => M | missense | 8.241e-06 | 1 | 121346 | 0 | 0.0 | 0.999 | LB (polar (hydrogen bond), polar (hydrogen bond with backbone)) |
5ht7r_human | 227 | ECL2 | D => E | missense | 8.24e-06 | 1 | 121356 | 0 | 0.33 | 0.542 | ||
5ht7r_human | 224 | ECL2 | N => K | missense | 8.241e-06 | 1 | 121346 | 0 | 0.04 | 0.992 | ||
5ht7r_human | 211 | 4.54x54 | TM4 | A => T | missense | 8.25e-06 | 1 | 121208 | 0 | 0.0 | 0.995 | |
5ht7r_human | 210 | 4.53x53 | TM4 | S => A | missense | 8.251e-06 | 1 | 121202 | 0 | 0.23 | 0.983 | |
5ht7r_human | 208 | 4.51x51 | TM4 | L => P | missense | 8.256e-06 | 1 | 121120 | 0 | 0.0 | 1.0 | |
5ht7r_human | 206 | 4.49x49 | TM4 | V => I | missense | 5.783e-05 | 7 | 121044 | 0 | 0.03 | 0.937 | |
5ht7r_human | 204 | 4.47x47 | TM4 | L => F | missense | 8.267e-06 | 1 | 120960 | 0 | 0.32 | 0.072 | |
5ht7r_human | 203 | 4.46x46 | TM4 | I => F | missense | 8.272e-06 | 1 | 120884 | 0 | 0.0 | 0.985 | |
5ht7r_human | 200 | 4.43x43 | TM4 | A => T | missense | 8.295e-06 | 1 | 120554 | 0 | 0.07 | 0.644 | |
5ht7r_human | 199 | 4.42x42 | TM4 | M => I | missense | 8.295e-06 | 1 | 120554 | 0 | 0.02 | 0.93 | |
5ht7r_human | 198 | 4.41x41 | TM4 | C => W | missense | 8.302e-06 | 1 | 120446 | 0 | 0.02 | 0.98 | |
5ht7r_human | 197 | 4.40x40 | TM4 | K => T | missense | 8.323e-06 | 1 | 120142 | 0 | 0.01 | 0.906 | |
5ht7r_human | 197 | 4.40x40 | TM4 | K => E | missense | 8.328e-06 | 1 | 120076 | 0 | 0.02 | 0.685 | |
5ht7r_human | 190 | 34.53x53 | ICL2 | Y => H | missense | 3.379e-05 | 4 | 118378 | 0 | 0.0 | 1.0 | GP (contact) |
5ht7r_human | 186 | 3.56x56 | TM3 | R => K | missense | 1.708e-05 | 2 | 117068 | 0 | 0.3 | 0.196 | GP (contact) |
5ht7r_human | 185 | 3.55x55 | TM3 | T => A | missense | 8.566e-06 | 1 | 116742 | 0 | 0.0 | 0.983 | GP (contact) |
5ht7r_human | 183 | 3.53x53 | TM3 | G => E | missense | 8.607e-06 | 1 | 116186 | 0 | 0.03 | 0.984 | GP (contact) |
5ht7r_human | 183 | 3.53x53 | TM3 | G => R | missense | 8.614e-06 | 1 | 116086 | 0 | 0.05 | 0.838 | GP (contact) |
5ht7r_human | 182 | 3.52x52 | TM3 | L => V | missense | 8.652e-06 | 1 | 115580 | 0 | 0.01 | 0.967 | |
5ht7r_human | 169 | 3.39x39 | TM3 | S => L | missense | 1.142e-05 | 1 | 87534 | 0 | 0.0 | 0.997 | |
5ht7r_human | 167 | 3.37x37 | TM3 | T => P | missense | 1.022e-05 | 1 | 97838 | 0 | 0.0 | 1.0 | LB (polar (hydrogen bond)) |
5ht7r_human | 156 | 3.26x26 | TM3 | N => T | missense | 8.459e-06 | 1 | 118212 | 0 | 0.0 | 0.999 | |
5ht7r_human | 152 | 3.22x22 | TM3 | H => Y | missense | 8.333e-06 | 1 | 120000 | 0 | 0.03 | 0.625 | |
5ht7r_human | 144 | 2.67x66 | TM2 | I => V | missense | 8.275e-06 | 1 | 120840 | 0 | 0.4 | 0.085 | |
5ht7r_human | 134 | 2.57x56 | TM2 | V => I | missense | 8.269e-06 | 1 | 120932 | 0 | 0.0 | 0.999 | |
5ht7r_human | 129 | 2.52x52 | TM2 | S => L | missense | 8.265e-06 | 1 | 120998 | 0 | 1.0 | 0.999 | |
5ht7r_human | 126 | 2.49x49 | TM2 | A => V | missense | 8.264e-06 | 1 | 121006 | 0 | 0.0 | 0.999 | |
5ht7r_human | 115 | 2.38x38 | TM2 | P => S | missense | 8.263e-06 | 1 | 121016 | 0 | 0.0 | 1.0 | |
5ht7r_human | 112 | 12.50x50 | ICL1 | L => F | missense | 8.264e-06 | 1 | 121012 | 0 | 0.0 | 1.0 | |
5ht7r_human | 104 | 1.55x55 | TM1 | I => T | missense | 8.268e-06 | 1 | 120948 | 0 | 0.07 | 0.999 | |
5ht7r_human | 92 | 1.43x43 | TM1 | T => A | missense | 8.294e-06 | 1 | 120564 | 0 | 0.13 | 0.907 | |
5ht7r_human | 91 | 1.42x42 | TM1 | I => T | missense | 8.296e-06 | 1 | 120534 | 0 | 0.0 | 0.917 | |
5ht7r_human | 90 | 1.41x41 | TM1 | L => F | missense | 8.308e-06 | 1 | 120372 | 0 | 0.17 | 0.691 | |
5ht7r_human | 89 | 1.40x40 | TM1 | T => A | missense | 2.493e-05 | 3 | 120320 | 0 | 0.64 | 0.002 | |
5ht7r_human | 86 | 1.37x37 | TM1 | S => C | missense | 1.665e-05 | 2 | 120130 | 0 | 0.05 | 0.413 | |
5ht7r_human | 85 | 1.36x36 | TM1 | G => D | missense | 8.332e-06 | 1 | 120026 | 0 | 0.02 | 1.0 | |
5ht7r_human | 84 | 1.35x35 | TM1 | I => V | missense | 8.34e-06 | 1 | 119900 | 0 | 0.13 | 0.47 | |
5ht7r_human | 80 | 1.31x31 | TM1 | E => G | missense | 8.368e-06 | 1 | 119496 | 0 | 0.01 | 0.94 | |
5ht7r_human | 79 | 1.30x30 | TM1 | V => I | missense | 0.0001927 | 23 | 119354 | 0 | 0.56 | 0.001 | |
5ht7r_human | 77 | 1.28x28 | TM1 | G => D | missense | 8.393e-06 | 1 | 119152 | 0 | 0.1 | 0.082 | |
5ht7r_human | 77 | 1.28x28 | TM1 | G => R | missense | 8.399e-06 | 1 | 119058 | 0 | 0.01 | 0.917 | |
5ht7r_human | 77 | 1.28x28 | TM1 | G => S | missense | 8.399e-06 | 1 | 119058 | 0 | 0.24 | 0.142 | |
5ht7r_human | 75 | N-term | N => K | missense | 8.415e-06 | 1 | 118840 | 0 | 0.58 | 0.164 | ||
5ht7r_human | 73 | N-term | Q => R | missense | 8.45e-06 | 1 | 118348 | 0 | 0.32 | 0.124 | ||
5ht7r_human | 70 | N-term | C => S | missense | 8.525e-06 | 1 | 117308 | 0 | nan | 0.999 | ||
5ht7r_human | 69 | N-term | G => S | missense | 6.841e-05 | 8 | 116940 | 1 | 0.75 | 0.013 | ||
5ht7r_human | 69 | N-term | G => R | missense | 3.421e-05 | 4 | 116940 | 0 | 0.58 | 0.007 | ||
5ht7r_human | 66 | N-term | N => T | missense | 8.67e-06 | 1 | 115338 | 0 | 0.03 | 0.234 | ||
5ht7r_human | 66 | N-term | N => S | missense | 8.67e-06 | 1 | 115338 | 0 | 0.12 | 0.015 | ||
5ht7r_human | 65 | N-term | D => V | missense | 2.622e-05 | 3 | 114424 | 0 | nan | 0.075 | ||
5ht7r_human | 64 | N-term | P => R | missense | 3.518e-05 | 4 | 113694 | 0 | nan | 0.002 | ||
5ht7r_human | 63 | N-term | P => S | missense | 1.777e-05 | 2 | 112572 | 0 | nan | 0.001 | ||
5ht7r_human | 62 | N-term | A => T | missense | 3.577e-05 | 4 | 111810 | 0 | 0.49 | 0.001 | ||
5ht7r_human | 60 | N-term | W => C | missense | 9.112e-05 | 10 | 109742 | 0 | nan | 0.312 | ||
5ht7r_human | 58 | N-term | P => S | missense | 9.496e-06 | 1 | 105310 | 0 | nan | 0.011 | ||
5ht7r_human | 57 | N-term | A => E | missense | 0.0002277 | 23 | 101014 | 0 | nan | 0.002 | ||
5ht7r_human | 57 | N-term | A => V | missense | 9.9e-06 | 1 | 101014 | 0 | nan | 0.001 | ||
5ht7r_human | 56 | N-term | P => L | missense | 9.763e-06 | 1 | 102430 | 0 | nan | 0.038 | ||
5ht7r_human | 55 | N-term | S => N | missense | 9.91e-06 | 1 | 100906 | 0 | nan | 0.013 | ||
5ht7r_human | 51 | N-term | E => Q | missense | 2.142e-05 | 2 | 93364 | 0 | nan | 0.173 | ||
5ht7r_human | 49 | N-term | L => Q | missense | 1.125e-05 | 1 | 88860 | 0 | nan | 0.277 | ||
5ht7r_human | 48 | N-term | L => R | missense | 1.164e-05 | 1 | 85904 | 0 | nan | 0.243 | ||
5ht7r_human | 39 | N-term | P => Q | missense | 5.907e-05 | 4 | 67722 | 0 | nan | 0.238 | ||
5ht7r_human | 39 | N-term | P => R | missense | 1.477e-05 | 1 | 67722 | 0 | nan | 0.227 | ||
5ht7r_human | 39 | N-term | P => T | missense | 1.481e-05 | 1 | 67504 | 0 | nan | 0.017 | ||
5ht7r_human | 37 | N-term | A => S | missense | 1.551e-05 | 1 | 64464 | 0 | nan | 0.048 | ||
5ht7r_human | 35 | N-term | G => S | missense | 3.146e-05 | 2 | 63570 | 0 | nan | 0.531 | ||
5ht7r_human | 34 | N-term | D => N | missense | 3.163e-05 | 2 | 63232 | 0 | nan | 0.734 | ||
5ht7r_human | 27 | N-term | G => R | missense | 3.242e-05 | 2 | 61684 | 0 | nan | 0.005 | ||
5ht7r_human | 27 | N-term | G => W | missense | 1.621e-05 | 1 | 61684 | 0 | nan | 0.663 | ||
5ht7r_human | 24 | N-term | V => A | missense | 1.577e-05 | 1 | 63426 | 0 | nan | 0.01 | ||
5ht7r_human | 24 | N-term | V => L | missense | 1.57e-05 | 1 | 63714 | 0 | nan | 0.001 | ||
5ht7r_human | 22 | N-term | P => L | missense | 1.559e-05 | 1 | 64128 | 0 | nan | 0.109 | ||
5ht7r_human | 20 | N-term | L => F | missense | 1.569e-05 | 1 | 63742 | 0 | nan | 0.002 | ||
5ht7r_human | 18 | N-term | S => F | missense | 1.578e-05 | 1 | 63352 | 0 | nan | 0.726 | ||
5ht7r_human | 17 | N-term | R => C | missense | 0.0001115 | 7 | 62782 | 0 | nan | 0.004 | ||
5ht7r_human | 17 | N-term | R => G | missense | 1.593e-05 | 1 | 62782 | 0 | nan | 0.048 | ||
5ht7r_human | 15 | N-term | H => R | missense | 1.604e-05 | 1 | 62346 | 0 | nan | 0.001 | ||
5ht7r_human | 8 | N-term | G => S | missense | 1.818e-05 | 1 | 55014 | 0 | nan | 0.105 | ||
5ht7r_human | 2 | N-term | M => I | missense | 0.0002386 | 10 | 41904 | 0 | nan | 0.01 |
Residue
- deleterious missense variants are shown in red
- tolerated missense variants are shown in green
- loss of function mutations ('stop gained' or 'frameshift' in the coding region) are shown in blue