Variation Browser

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Receptor Position GPCRdb Segment Variant Mutation type Allele Frequency Allele Count Allele Number Homozygotes SIFT score PolyPhen score Functional annotation
Receptor Position GPCRdb Segment Variant Mutation Type Allele Frequency Allele Count Allele Number Homozygotes SIFT score PolyPhen score Functional annotation
5ht7r_human 474 C-term K => SerfsTer2 frameshift 8.303e-06 1 120438 0 None None
5ht7r_human 462 C-term W => Ter stop gained 8.241e-06 1 121346 0 None None
5ht7r_human 403 8.62x62 H8 Y => Ter stop gained 8.238e-06 1 121382 0 None None
5ht7r_human 301 ICL3 E => Ter stop gained 8.266e-06 1 120976 0 None None
5ht7r_human 221 ECL2 W => Ter stop gained 8.242e-06 1 121328 0 None None
5ht7r_human 470 C-term T => A missense 8.324e-06 1 120138 0 nan 0.003
5ht7r_human 466 C-term K => Q missense 8.355e-06 1 119682 0 nan 0.952
5ht7r_human 464 C-term A => V missense 1.648e-05 2 121344 0 nan 0.0
5ht7r_human 464 C-term A => T missense 8.241e-06 1 121342 0 nan 0.0
5ht7r_human 457 C-term P => S missense 8.24e-06 1 121360 0 nan 0.0
5ht7r_human 454 C-term L => P missense 8.24e-06 1 121364 0 nan 0.0
5ht7r_human 454 C-term L => V missense 8.24e-06 1 121364 0 nan 0.0
5ht7r_human 451 C-term V => L missense 1.648e-05 2 121374 0 nan 0.0
5ht7r_human 449 C-term V => A missense 7.415e-05 9 121368 0 1.0 0.0
5ht7r_human 449 C-term V => L missense 8.239e-06 1 121368 0 nan 0.0
5ht7r_human 448 C-term P => R missense 0.008265 1003 121356 13 nan 0.0
5ht7r_human 448 C-term P => L missense 4.944e-05 6 121356 1 nan 0.0
5ht7r_human 448 C-term P => T missense 8.24e-06 1 121358 0 nan 0.0
5ht7r_human 448 C-term P => S missense 8.24e-06 1 121358 0 nan 0.0
5ht7r_human 446 C-term R => K missense 1.648e-05 2 121354 0 nan 0.001
5ht7r_human 445 C-term K => N missense 0.0003049 37 121354 0 nan 0.0
5ht7r_human 443 C-term P => S missense 1.648e-05 2 121344 0 nan 0.001
5ht7r_human 439 C-term V => L missense 8.241e-06 1 121344 0 nan 0.0
5ht7r_human 433 C-term R => K missense 8.244e-06 1 121296 0 nan 0.0
5ht7r_human 427 C-term R => K missense 8.355e-06 1 119682 0 nan 0.001
5ht7r_human 427 C-term R => G missense 8.349e-06 1 119770 0 nan 0.027
5ht7r_human 425 C-term P => T missense 8.317e-06 1 120234 0 nan 0.65
5ht7r_human 416 C-term H => R missense 3.302e-05 4 121130 0 0.11 0.999
5ht7r_human 416 C-term H => L missense 8.256e-06 1 121130 0 0.01 0.999
5ht7r_human 410 C-term L => F missense 2.473e-05 3 121318 0 0.0 0.999
5ht7r_human 405 C-term N => T missense 8.24e-06 1 121360 0 0.03 0.983
5ht7r_human 400 8.59x59 H8 Q => R missense 8.238e-06 1 121390 0 0.5 0.003
5ht7r_human 400 8.59x59 H8 Q => E missense 8.238e-06 1 121392 0 0.27 0.117
5ht7r_human 396 8.55x55 H8 R => C missense 8.237e-06 1 121402 0 0.0 0.886
5ht7r_human 389 8.48x48 H8 R => Q missense 8.237e-06 1 121398 0 0.03 1.0 GP (contact)
5ht7r_human 389 8.48x48 H8 R => W missense 1.648e-05 2 121396 0 0.0 1.0 GP (contact)
5ht7r_human 382 7.51x51 TM7 F => L missense 8.238e-06 1 121390 0 0.59 0.084
5ht7r_human 378 7.47x47 TM7 L => F missense 1.648e-05 2 121372 0 0.19 0.999
5ht7r_human 377 7.46x46 TM7 S => C missense 8.24e-06 1 121366 0 0.03 1.0
5ht7r_human 372 7.41x40 TM7 L => P missense 8.241e-06 1 121342 0 0.0 1.0
5ht7r_human 369 7.38x37 TM7 F => C missense 8.242e-06 1 121330 0 0.11 0.03
5ht7r_human 362 7.31x30 TM7 P => S missense 1.649e-05 2 121294 0 0.02 1.0
5ht7r_human 358 ECL3 C => Y missense 8.246e-06 1 121274 0 0.01 1.0
5ht7r_human 358 ECL3 C => F missense 8.246e-06 1 121274 0 0.01 1.0
5ht7r_human 356 ECL3 T => S missense 8.246e-06 1 121264 0 0.55 0.039
5ht7r_human 349 6.57x57 TM6 A => V missense 1.649e-05 2 121250 0 0.71 0.999
5ht7r_human 346 6.54x54 TM6 L => I missense 8.248e-06 1 121238 0 0.04 0.817
5ht7r_human 344 6.52x52 TM6 F => I missense 8.249e-06 1 121232 0 0.0 1.0 LB (aromatic (edge-to-face), polar (hydrogen bond))
5ht7r_human 338 6.46x46 TM6 V => M missense 3.3e-05 4 121214 0 0.06 0.104
5ht7r_human 337 6.45x45 TM6 T => I missense 8.249e-06 1 121224 0 0.08 0.889
5ht7r_human 335 6.43x43 TM6 A => V missense 3.3e-05 4 121218 0 0.08 0.534
5ht7r_human 335 6.43x43 TM6 A => T missense 8.249e-06 1 121220 0 0.02 0.983
5ht7r_human 335 6.43x43 TM6 A => S missense 1.65e-05 2 121220 0 0.01 0.98
5ht7r_human 333 6.41x41 TM6 V => I missense 3.3e-05 4 121194 0 0.02 0.958
5ht7r_human 326 6.34x34 TM6 A => T missense 8.251e-06 1 121192 0 0.22 0.999 SodiumPocket MicroSwitch
5ht7r_human 325 6.33x33 TM6 A => V missense 8.251e-06 1 121192 0 0.03 0.999 GP (contact)
5ht7r_human 299 ICL3 V => M missense 8.266e-06 1 120982 0 0.13 0.905
5ht7r_human 292 ICL3 I => K missense 1.653e-05 2 120976 0 0.89 0.004
5ht7r_human 292 ICL3 I => V missense 8.266e-06 1 120978 0 0.53 0.002
5ht7r_human 286 ICL3 V => I missense 8.266e-05 10 120982 0 0.22 0.01
5ht7r_human 285 ICL3 S => N missense 8.263e-06 1 121024 0 0.51 0.395 PTM (Phosphorylation)
5ht7r_human 285 ICL3 S => G missense 1.653e-05 2 121020 0 0.43 0.006 PTM (Phosphorylation)
5ht7r_human 284 ICL3 D => H missense 8.263e-06 1 121024 0 0.15 0.617
5ht7r_human 280 ICL3 R => Q missense 9.089e-05 11 121030 0 0.11 0.124
5ht7r_human 279 ICL3 P => L missense 0.002049 248 121050 0 0.0 0.082
5ht7r_human 271 5.70x70 TM5 A => G missense 8.251e-06 1 121202 0 0.1 0.88
5ht7r_human 261 5.60x60 TM5 Q => R missense 2.473e-05 3 121306 0 0.75 0.006
5ht7r_human 258 5.57x57 TM5 M => T missense 8.244e-06 1 121302 0 0.0 0.998
5ht7r_human 258 5.57x57 TM5 M => V missense 8.244e-06 1 121304 0 0.38 0.994
5ht7r_human 256 5.55x55 TM5 L => I missense 8.243e-06 1 121312 0 0.18 0.999
5ht7r_human 254 5.53x53 TM5 V => I missense 1.649e-05 2 121316 0 0.05 0.923
5ht7r_human 254 5.53x53 TM5 V => F missense 8.243e-06 1 121316 0 0.0 0.999
5ht7r_human 249 5.48x48 TM5 Y => F missense 8.242e-06 1 121328 0 0.0 1.0
5ht7r_human 241 5.40x41 TM5 I => S missense 8.241e-06 1 121348 0 0.0 0.959
5ht7r_human 240 5.39x40 TM5 T => M missense 8.241e-06 1 121346 0 0.0 0.999 LB (polar (hydrogen bond), polar (hydrogen bond with backbone))
5ht7r_human 227 ECL2 D => E missense 8.24e-06 1 121356 0 0.33 0.542
5ht7r_human 224 ECL2 N => K missense 8.241e-06 1 121346 0 0.04 0.992
5ht7r_human 211 4.54x54 TM4 A => T missense 8.25e-06 1 121208 0 0.0 0.995
5ht7r_human 210 4.53x53 TM4 S => A missense 8.251e-06 1 121202 0 0.23 0.983
5ht7r_human 208 4.51x51 TM4 L => P missense 8.256e-06 1 121120 0 0.0 1.0
5ht7r_human 206 4.49x49 TM4 V => I missense 5.783e-05 7 121044 0 0.03 0.937
5ht7r_human 204 4.47x47 TM4 L => F missense 8.267e-06 1 120960 0 0.32 0.072
5ht7r_human 203 4.46x46 TM4 I => F missense 8.272e-06 1 120884 0 0.0 0.985
5ht7r_human 200 4.43x43 TM4 A => T missense 8.295e-06 1 120554 0 0.07 0.644
5ht7r_human 199 4.42x42 TM4 M => I missense 8.295e-06 1 120554 0 0.02 0.93
5ht7r_human 198 4.41x41 TM4 C => W missense 8.302e-06 1 120446 0 0.02 0.98
5ht7r_human 197 4.40x40 TM4 K => T missense 8.323e-06 1 120142 0 0.01 0.906
5ht7r_human 197 4.40x40 TM4 K => E missense 8.328e-06 1 120076 0 0.02 0.685
5ht7r_human 190 34.53x53 ICL2 Y => H missense 3.379e-05 4 118378 0 0.0 1.0 GP (contact)
5ht7r_human 186 3.56x56 TM3 R => K missense 1.708e-05 2 117068 0 0.3 0.196 GP (contact)
5ht7r_human 185 3.55x55 TM3 T => A missense 8.566e-06 1 116742 0 0.0 0.983 GP (contact)
5ht7r_human 183 3.53x53 TM3 G => E missense 8.607e-06 1 116186 0 0.03 0.984 GP (contact)
5ht7r_human 183 3.53x53 TM3 G => R missense 8.614e-06 1 116086 0 0.05 0.838 GP (contact)
5ht7r_human 182 3.52x52 TM3 L => V missense 8.652e-06 1 115580 0 0.01 0.967
5ht7r_human 169 3.39x39 TM3 S => L missense 1.142e-05 1 87534 0 0.0 0.997
5ht7r_human 167 3.37x37 TM3 T => P missense 1.022e-05 1 97838 0 0.0 1.0 LB (polar (hydrogen bond))
5ht7r_human 156 3.26x26 TM3 N => T missense 8.459e-06 1 118212 0 0.0 0.999
5ht7r_human 152 3.22x22 TM3 H => Y missense 8.333e-06 1 120000 0 0.03 0.625
5ht7r_human 144 2.67x66 TM2 I => V missense 8.275e-06 1 120840 0 0.4 0.085
5ht7r_human 134 2.57x56 TM2 V => I missense 8.269e-06 1 120932 0 0.0 0.999
5ht7r_human 129 2.52x52 TM2 S => L missense 8.265e-06 1 120998 0 1.0 0.999
5ht7r_human 126 2.49x49 TM2 A => V missense 8.264e-06 1 121006 0 0.0 0.999
5ht7r_human 115 2.38x38 TM2 P => S missense 8.263e-06 1 121016 0 0.0 1.0
5ht7r_human 112 12.50x50 ICL1 L => F missense 8.264e-06 1 121012 0 0.0 1.0
5ht7r_human 104 1.55x55 TM1 I => T missense 8.268e-06 1 120948 0 0.07 0.999
5ht7r_human 92 1.43x43 TM1 T => A missense 8.294e-06 1 120564 0 0.13 0.907
5ht7r_human 91 1.42x42 TM1 I => T missense 8.296e-06 1 120534 0 0.0 0.917
5ht7r_human 90 1.41x41 TM1 L => F missense 8.308e-06 1 120372 0 0.17 0.691
5ht7r_human 89 1.40x40 TM1 T => A missense 2.493e-05 3 120320 0 0.64 0.002
5ht7r_human 86 1.37x37 TM1 S => C missense 1.665e-05 2 120130 0 0.05 0.413
5ht7r_human 85 1.36x36 TM1 G => D missense 8.332e-06 1 120026 0 0.02 1.0
5ht7r_human 84 1.35x35 TM1 I => V missense 8.34e-06 1 119900 0 0.13 0.47
5ht7r_human 80 1.31x31 TM1 E => G missense 8.368e-06 1 119496 0 0.01 0.94
5ht7r_human 79 1.30x30 TM1 V => I missense 0.0001927 23 119354 0 0.56 0.001
5ht7r_human 77 1.28x28 TM1 G => D missense 8.393e-06 1 119152 0 0.1 0.082
5ht7r_human 77 1.28x28 TM1 G => R missense 8.399e-06 1 119058 0 0.01 0.917
5ht7r_human 77 1.28x28 TM1 G => S missense 8.399e-06 1 119058 0 0.24 0.142
5ht7r_human 75 N-term N => K missense 8.415e-06 1 118840 0 0.58 0.164
5ht7r_human 73 N-term Q => R missense 8.45e-06 1 118348 0 0.32 0.124
5ht7r_human 70 N-term C => S missense 8.525e-06 1 117308 0 nan 0.999
5ht7r_human 69 N-term G => S missense 6.841e-05 8 116940 1 0.75 0.013
5ht7r_human 69 N-term G => R missense 3.421e-05 4 116940 0 0.58 0.007
5ht7r_human 66 N-term N => T missense 8.67e-06 1 115338 0 0.03 0.234
5ht7r_human 66 N-term N => S missense 8.67e-06 1 115338 0 0.12 0.015
5ht7r_human 65 N-term D => V missense 2.622e-05 3 114424 0 nan 0.075
5ht7r_human 64 N-term P => R missense 3.518e-05 4 113694 0 nan 0.002
5ht7r_human 63 N-term P => S missense 1.777e-05 2 112572 0 nan 0.001
5ht7r_human 62 N-term A => T missense 3.577e-05 4 111810 0 0.49 0.001
5ht7r_human 60 N-term W => C missense 9.112e-05 10 109742 0 nan 0.312
5ht7r_human 58 N-term P => S missense 9.496e-06 1 105310 0 nan 0.011
5ht7r_human 57 N-term A => E missense 0.0002277 23 101014 0 nan 0.002
5ht7r_human 57 N-term A => V missense 9.9e-06 1 101014 0 nan 0.001
5ht7r_human 56 N-term P => L missense 9.763e-06 1 102430 0 nan 0.038
5ht7r_human 55 N-term S => N missense 9.91e-06 1 100906 0 nan 0.013
5ht7r_human 51 N-term E => Q missense 2.142e-05 2 93364 0 nan 0.173
5ht7r_human 49 N-term L => Q missense 1.125e-05 1 88860 0 nan 0.277
5ht7r_human 48 N-term L => R missense 1.164e-05 1 85904 0 nan 0.243
5ht7r_human 39 N-term P => Q missense 5.907e-05 4 67722 0 nan 0.238
5ht7r_human 39 N-term P => R missense 1.477e-05 1 67722 0 nan 0.227
5ht7r_human 39 N-term P => T missense 1.481e-05 1 67504 0 nan 0.017
5ht7r_human 37 N-term A => S missense 1.551e-05 1 64464 0 nan 0.048
5ht7r_human 35 N-term G => S missense 3.146e-05 2 63570 0 nan 0.531
5ht7r_human 34 N-term D => N missense 3.163e-05 2 63232 0 nan 0.734
5ht7r_human 27 N-term G => R missense 3.242e-05 2 61684 0 nan 0.005
5ht7r_human 27 N-term G => W missense 1.621e-05 1 61684 0 nan 0.663
5ht7r_human 24 N-term V => A missense 1.577e-05 1 63426 0 nan 0.01
5ht7r_human 24 N-term V => L missense 1.57e-05 1 63714 0 nan 0.001
5ht7r_human 22 N-term P => L missense 1.559e-05 1 64128 0 nan 0.109
5ht7r_human 20 N-term L => F missense 1.569e-05 1 63742 0 nan 0.002
5ht7r_human 18 N-term S => F missense 1.578e-05 1 63352 0 nan 0.726
5ht7r_human 17 N-term R => C missense 0.0001115 7 62782 0 nan 0.004
5ht7r_human 17 N-term R => G missense 1.593e-05 1 62782 0 nan 0.048
5ht7r_human 15 N-term H => R missense 1.604e-05 1 62346 0 nan 0.001
5ht7r_human 8 N-term G => S missense 1.818e-05 1 55014 0 nan 0.105
5ht7r_human 2 N-term M => I missense 0.0002386 10 41904 0 nan 0.01


Residue

Diagrams

ICL1 K K L R ICL1ECL1 K W I F ECL1ICL2 P L T Y P V R Q ICL2ECL2 W A Q N V N D D K V C L I S Q ECL2ICL3 F P R V E P D S V I A L N G I V K L Q K E V E E C A N L S R L L K H E R K N ICL3ECL3 C G T S C S C I ECL3N-term M M D V N S S G R P D L Y G H L R S F L L P E V G R G L P D L S P D G G A D P V A G S W A P H L L S E V T A S P A P T W D A P P D N A S G C G E Q I N Y N-termC-term R N I N R K L S A A G M H E A L K L A E R P E R P E F V L R A C T R R V L L R P E K R P P V S V W V L Q S P D H H N W L A D K M L T T V E K K V M I H D C-term G R V E K V V I G S I L T L I T L L T I A G N C L V V I S V C F V Q P S N Y L I V S L A L A D L S V A V A V M P F V S V T D L I G G G H F F C N V F I A M D V M C C T A S I M T L C V I S I D R Y L G I T R N G K C M A K M I L S V W L L S A S I T L P P L F G D F G Y T I Y S T A V A F Y I P M S V M L F M Y Y Q I Y K A A R K S A A K H K F P G I S I F K R E Q K A A T T L G I I V G A F T V C W L P F F L L S T A R P F I P L W V E R T F L W L G Y A N S L I N P F I Y A F F N R D Y R S Q Y L R T T L L Q C
SnakePlot Download: PNG | SVG C N G A I T L L T I L T L I S G I V V K 1 V S L A L A D L S V A A V V M P F V S V T 2 V C L T M I S A T C C M V D M A I F V N 3 M A K M I L S V W L L S A S I T L P P L 4 Y M F L M V S M P I Y F A V A T S Y I T Y 5 G I I V G A F T V C W L P F F L L S T A 6 F P N I L S N A Y G L W L F T R E V W 7
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